Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-Sap
This immunotoxin was achieved by conjugating/fusing the Anti-TNFRSF8 scFv to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to TNFRSF8 overexpressed malignant lymphoma cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of malignant lymphoma.
| Supplier | Creative Biolabs |
|---|---|
| Product # | AGTO-G062S |
| Pricing | Inquiry |
| Applications | This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy. |
| Host | Mouse |
| Target | TNFRSF8 |
| Species Reactivity | Human |