NLX-204 HCl
NLX-204 is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist with pKi = 10.19. NLX-204 displayed high selectivity in the SafetyScreen44 panel (including hERG channel), high solubility, metabolic stability, and Caco-2 penetration and did not block CYP3A4, CYP2D6 isoenzymes, or P-glycoprotein. Preliminary in vivo studies confirmed its promising pharmacokinetic profile. NLX-204 also robustly stimulated ERK1/2 phosphorylation in rat cortex and showed highly potent (MED = 0.16 mg/kg) and efficacious antidepressant-like activity, totally eliminating immobility in the rat Porsolt test.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1044 |
| CAS # | 2170405-10-2 (free base) |
| Pricing | Customizable size, Inquiry |
| Synonym | NLX-204; NLX204; NLX204; NLX-204 HCl; NLX-204 hydrochloride; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C20H23Cl2F2N3O2 |
| Exact Mass | 409.1369 |
| Molecular Weight | 445.1135 |
| Elemental Analysis | C, 53.82; H, 5.19; Cl, 15.89; F, 8.51; N, 9.41; O, 7.17 |
| IUPAC/Chemical Name | (3-chloro-4-fluorophenyl)(4-fluoro-4-(((2-(pyridin-2-yloxy)ethyl)amino)methyl)piperidin-1-yl)methanone hydrochloride |
| InChi Key | ANOJKCJEWKVZDV-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C20H22ClF2N3O2.ClH/c21-16-13-15(4-5-17(16)22)19(27)26-10-6-20(23,7-11-26)14-24-9-12-28-18-3-1-2-8-25-18;/h1-5,8,13,24H,6-7,9-12,14H2;1H |
| SMILES Code | O=C(C1=CC=C(F)C(Cl)=C1)N2CCC(CNCCOC3=NC=CC=C3)(F)CC2.[H]Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |