Autocamtide-2-RelatedInhibitoryPeptide

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Supplier	Creative Peptides
Product #	R1857
CAS #	167114-91-2
Pricing	Inquire
Synonyms	AIP, [Ala9]-Autocamtide 2
MolecularFormula	C64H116N22O19
MolecularWeight	1497.74
Source	Synthetic
Sequence	One Letter Code: KKALRRQEAVDAL Three Letter Code: Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu
Storage	-20 degrees Celsius away from light
ShippingCondition	Wet ice in continental US; may vary elsewhere
Explanation	Autocamtide-2-Related Inhibitory Peptide is a highly specific and potent inhibitor of CaMKII
Activity	Selective and potent calmodulin-dependent protein kinase II (CaM kinase II) inhibitor (IC50 = 40 nM). Selective over PKC, PKA and CaM kinase IV (IC50 > 10 μM).
InChI	1S/C65H114N20O21/c1-32(2)28-46(63(105)106)85-54(96)36(7)78-62(104)45(31-52(93)94)84-56(98)38(33(3)4)30-47(86)34(5)76-59(101)43(19-22-50(89)90)81-55(97)37(18-21-49(69)88)29-48(87)40(16-12-26-74-64(70)71)79-60(102)42(17-13-27-75-65(72)73)83-61(103)44(20-23-51(91)92)80-53(95)35(6)77-58(100)41(15-9-11-25-67)82-57(99)39(68)14-8-10-24-66/h32-46H,8-31,66-68H2,1-7H3,(H2,69,88)(H,76,101)(H,77,100)(H,78,104)(H,79,102)(H,80,95)(H,81,97)(H,82,99)(H,83,103)(H,84,98)(H,85,96)(H,89,90)(H,91,92)(H,93,94)(H,105,106)(H4,70,71,74)(H4,72,73,75)/t34-,35-,36-,37+,38-,39-,40-,41-,42-,43-,44-,45-,46-/m0/s1
InChIKey	COEHZSYVSXUBHI-CYZNULJVSA-N
CanonicalSMILES	CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)CC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(C)C)C(O)=O
Solubility	Soluble to 1 mg/ml in water
Purity	≥97% (HPLC)

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