| Supplier |
Creative Peptides |
| Product # |
Z10-101-155 |
| CAS # |
159351-69-6 |
| Pricing |
Inquire
|
| Synonyms |
Afinitor; Certican; Zortress; RAD001; SDZ-RAD
|
| MolecularFormula |
C53H83NO14
|
| MolecularWeight |
958.24
|
| Storage |
−20°C
|
| ShippingCondition |
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
|
| Explanation |
Everolimus is a Kinase Inhibitor and mTOR Inhibitor Immunosuppressant. The mechanism of action of everolimus is as a Protein Kinase Inhibitor and Cytochrome P450 3A4 Inhibitor and P-Glycoprotein Inhibitor and Cytochrome P450 2D6 Inhibitor and mTOR Inhibitor. The physiologic effect of everolimus is by means of Decreased Immunologic Activity.
|
| Application |
Everolimus is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
|
| Activity |
Inhibitor
|
| InChI |
InChI=1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1
|
| InChIKey |
HKVAMNSJSFKALM-GKUWKFKPSA-N
|
| Solubility |
Soluble in DMSO, not in water
|
| IsomericSMILES |
C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OCCO)C)/C)O)OC)C)C)/C)OC
|
| Appearance |
White to off-white solid powder
|
| BiologicalActivity |
Everolimus, also known as RAD001, is a derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties.
|
| Target |
mTOR
|
| Purity |
>98% (or refer to the Certificate of Analysis)
|
| AreasOfInterest |
Kinase Inhibitor
|
| ShortTermStorageConditions |
Dry, dark and at 0 - 4 °C
|
| LongTermStorageConditions |
-20 °C
|
| Functions |
Tfiiic-class transcription factor binding
|
| Disease |
- Carcinoma of breast;
- Renal cell carcinoma;
- Prevention of Kidney Transplant Rejection;
- Pancreatic Neuroendocrine Tumor
|
| Organism |
Human
|
| LabelingTarget |
Serine/threonine-protein kinase mTOR
|
| BoilingPoint |
998.7±75.0 °C at 760 mmHg
|