bile acid-CoA:amino acid N-acyltransferase

Also acts on CoA derivatives of other bile acids. Taurine and 2-fluoro-β-alanine can act as substrates, but more slowly. The enzyme can also conjugate fatty acids to glycine and can act as a very-long-chain acyl-CoA thioesterase. Bile-acid-amino-acid conjugates serve as detergents in the gastrointestinal tract, solubilizing long chain fatty acids, mono- and diglycerides, fat-soluble vitamins and cholesterol. This is the second enzyme in a two-step process leading to the conjugation of bile acids with amino acids; the first step is the conversion of bile acids into their acyl-CoA thioesters, which is catalysed by EC 6.2.1.7, cholate-CoA ligase.

• Supplier: Creative Enzymes
• Product #: EXWM-2245
• CAS: 65979-40-0