HRGβ2-PE immunotoxin

This immunotoxin was achieved by conjugating/fusing the HRGβ2 to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cells overexpressing erbB3 and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of prostate, gastric and pancreatic cancers.
Supplier Creative Biolabs
Product # AGTO-L074E
Pricing Inquiry
Applications This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Host Human
Target ERBB3
Species Reactivity Human
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