Igmesine Hydrochloride
Igmesine, also known as JO-1784 and CI1019, is a selective and potent σ1 receptor ligand (KD = 19.1 nM), with little or no activity at σ2 receptors (IC50 > 1000 nM). It inhibits the NMDA-induced increase in cGMP in a concentration-dependent manner (IC50 value is approximately 100 nM). Igmesine Hydrochloride is a weak inhibitor of brain 5-HT uptake in vitro. It exhibits neuroprotective and antidepressant effects.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD897 |
| CAS # | 130152-35-1 (HCl) |
| Pricing | Customizable size, Inquiry |
| Synonym | Igmesine Hydrochloride; Igmesine HCl; CI 1019; CI-1019; JO-1784; JO 1784; JO1784. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C23H30ClN |
| Molecular Weight | 355.94 |
| Elemental Analysis | C, 77.61; H, 8.50; Cl, 9.96; N, 3.94 |
| IUPAC/Chemical Name | (+)-(E)-N-(Cyclopropylmethyl)-alpha-ethyl-N-methyl-alpha-(3-phenyl-2-propenyl)benzenemethanamine hydrochloride |
| InChi Key | SCHQQPAJNUHKSV-RSGUCCNWSA-N |
| InChi Code | InChI=1S/C23H29N.ClH/c1-3-23(22-14-8-5-9-15-22,24(2)19-21-16-17-21)18-10-13-20-11-6-4-7-12-20;/h4-15,21H,3,16-19H2,1-2H3;1H/b13-10+; |
| SMILES Code | CN(CC1CC1)C(C/C=C/C2=CC=CC=C2)(CC)C3=CC=CC=C3.[H]Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |