| Supplier |
CD Formulation |
| Product # |
PE-0486 |
| Pricing |
, Inquire for price
|
| product1 |
Pharmaceutical Excipients
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| Molecular Formula |
C6H12NNaO3S
|
| Molecular Weight |
201.22
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| Applications |
As a strong sweetener, sodium cyclolatate can be used in pharmaceutical preparations, food, beverage and catering. Its dilute solution of about 0.17%w/v is about 30 times sweeter than sucrose. However, the sweetness decreases with increasing concentration and there is a marked bitterness when the concentration reaches 0.5%w/v. Sodium cylatate enhances the taste system and can be used to mask certain undesirable tastes. In most cases, sodium cylatate is used in combination with saccharin.
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| CAS Number |
139-05-9
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| Category |
Sweetening agent
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| Chemical Name |
Sodium N-cyclohexylsulfamate
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| Grade |
Pharmceutical Excipients
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| Stability and Storage Conditions |
Sodium cyclolatate is hydrolyzed slowly by sulfuric acid and cyclohexylamine at a rate proportional to hydrogen ion concentration. Therefore, it is relatively stable in practice. The solution is stable to light, heat and air over a fairly wide pH range. Tablets containing sodium cylatate and saccharin showed no decrease in sweetness after up to 20 years of storage. Raw materials should be stored in an airtight container and kept in a cool and dry place.
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| Source and Preparation |
This product is prepared by sulfonic acid reaction of cyclohexylamine under alkaline conditions. Commercially, sulfonating agents include sulfamic acid, sulfate, or sulfur trioxide. Quaternary amine compounds such as trihexamine or trimethylamine can be used as binding agents. The resulting cyclohexylate amine salt is treated with appropriate metal oxides, and the corresponding sodium salt, calcium salt, potassium salt or magnesium salt can be prepared.
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