Amorfrutin B

Amorfrutin B is a partial agonist of the peroxisome proliferator-activated receptor γ (PPARγ; Ki = 19 nM and EC50 = 73 nM) that was first isolated from A. fruticosa. Amorfrutin B has low nanomolar binding affinity to pparγ and micromolar binding to the isotypes pparα and pparβ/δ, the binding affinity constant to ppargamma is 12 times lower than amorfrutin a, antidiabetic agent, glucose-lowering agent, antimicrobial agent. It binds to PPARα with 2.6 µM and PPARβ/δ with Ki values of 1.7 µM. Amorfrutin is a glucose-lowering agent and can improves insulin sensitivity, glucose tolerance and blood lipid variables without increase of fat storage or hepatoxicity.

• Supplier: BOC Sciences
• Product #: 78916-42-4
• Cas: 78916-42-4
• Molecular Weight: 408.5
• Molecular Formula: C26H32O4
• Canonical SMILES: OC(C(C(O)=C(C/C=C(C)/CC/C=C(C)/C)C(OC)=C1)=C1CCC2=CC=CC=C2)=O