Lecozotan HCl
Lecozotan, also known as SRA-333, is a potent and selective 5-HT antagonist potentially for the treatment of Alzheimer's disease. Lecozotan (SRA-333) enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. Lecozotan significantly potentiated the potassium chloride-stimulated release of glutamate and acetylcholine in the dentate gyrus of the hippocampus. Chronic administration of lecozotan did not induce 5-HT(1A) receptor tolerance or desensitization in a behavioral model indicative of 5-HT(1A) receptor function. Acute lecozotan administration increases learning and memory in rats without affecting anxiety or behavioral depression.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD254 |
| CAS # | 433282-68-9 (HCl) |
| Pricing | Customizable size, Inquiry |
| Synonym | SRA-333; SRA333; SRA 333; Lecozotan HCl; Lecozotan hydrochloride. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C28H30ClN5O3 |
| Molecular Weight | 520.03 |
| Elemental Analysis | C, 64.67; H, 5.82; Cl, 6.82; N, 13.47; O, 9.23 |
| IUPAC/Chemical Name | Benzamide, 4-cyano-N-((2R)-2-(4-(2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl)propyl)-N-2-pyridinyl-, monohydrochloride |
| InChi Key | GXYZREDEYDFJPT-ZMBIFBSDSA-N |
| InChi Code | InChI=1S/C28H29N5O3.ClH/c1-21(31-13-15-32(16-14-31)24-5-4-6-25-27(24)36-18-17-35-25)20-33(26-7-2-3-12-30-26)28(34)23-10-8-22(19-29)9-11-23;/h2-12,21H,13-18,20H2,1H3;1H/t21-;/m1./s1 |
| SMILES Code | O=C(N(C[C@H](N1CCN(C2=C3OCCOC3=CC=C2)CC1)C)C4=NC=CC=C4)C5=CC=C(C#N)C=C5.[H]Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |