Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-RTA
This immunotoxin was achieved by conjugating/fusing the Anti-TNFRSF8 scFv to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to TNFRSF8 overexpressed malignant lymphoma cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of malignant lymphoma.
Supplier | Creative Biolabs |
---|---|
Product # | AGTO-G062R |
Pricing | Inquiry |
Applications | This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy. |
Host | Mouse |
Target | TNFRSF8 |
Species Reactivity | Human |