Nuclear Prelamin A Recognition Factor (NARF) Antibody
Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing.
Supplier | Abbexa Ltd. |
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Product # | abx029464-400UL |
Pricing | 400 µl USD $601.75 |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Host | Rabbit |
Tested Applications | ELISA, WB |
UniProt Primary AC | Q9UHQ1 |
Dry Ice | No |
Availability | Shipped within 5-10 working days. |
Note | This product is for research use only. |