AMG-548 dihydrochloride
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-108642B-10 mM * 1 mL |
| Pricing | 10 mM * 1 mL, USD $317.0 |
| Biological Activity | AMG-548 dihydrochloride, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 dihydrochloride is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM)[1]. AMG-548 dihydrochloride inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε[2]. |
| Purity | ≥98.0% |
| MWt | 534.48 |
| Formula | C₂₉H₂₉Cl₂N₅O |