Oleyl Alcohol
Oleyl alcohol occurs as a pale yellow oily liquid that gives off acrid fumes when heated.
| Supplier | CD Formulation |
|---|---|
| Product # | PE-0555 |
| Pricing | , Inquire for price |
| product1 | Excipients for Liquid Dosage Form |
| Molecular Formula | C18H36O |
| Molecular Weight | 268.48 |
| Applications | Oleyl alcohol is mainly used in topical pharmaceutical formulations and has been used in transdermal delivery formulations.It has been utilized in the development of biodegradable injectable thermoplastic oligomers, and in aerosol formulations of insulin and albuterol. Therapeutically, it has been suggested that oleyl alcohol may exhibit antitumor properties via transmembrane permeation. |
| Safety | Oleyl alcohol is mainly used in topical pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material at the levels employed as an excipient. However, contact dermatitis due to oleyl alcohol has been reported. The results of acute oral toxicity and percutaneous studies in animals with products containing 8% oleyl alcohol indicate a very low toxicity. Formulations containing 8% or 20% oleyl alcohol administered by gastric intubation, at doses up to 10 g/kg bodyweight, caused no deaths and no toxic effects in rats. |
| Synonyms | Alcohol oleicus; HD-Eutanol V PH; Novol; Ocenol; cis-9- octadecen-1-ol; oleic alcohol; oleo alcohol; oleol |
| CAS Number | 143-28-2 |
| Category | Antifoaming Agents; emollient; EmulsifyingAgents; Skin Penetrant; Sustained-release Agents |
| UNII | 172F2WN8DV |
| Chemical Name | (Z)-9-Octadecen-1-ol |
| Grade | Pharmceutical Excipients |
| Administration route | Topical |
| Dosage Form | Topical emulsions and ointments |
| Stability and Storage Conditions | The bulk material should be stored in a well-closed container in a cool, dry, place. |
| Source and Preparation | Oleyl alcohol occurs naturally in fish oils. Synthetically, it can be prepared from butyl oleate by a Bouveault-Blanc reduction with sodium and butyl alcohol. An alternative method of manufacture is by the hydrogenation of triolein in the presence of zinc chromite. |