(S,R,S)-AHPC hydrochloride

Supplier MedChemExpress
Product # HY-101763A-100 mg
CAS # 1448189-80-7
Pricing 100 mg, USD $300.0
Synonyms VH032-NH2 hydrochloride; VHL ligand 1 hydrochloride
MWt 467.02
Formula C₂₂H₃₁ClN₄O₃S
Biological Activity (S,R,S)-AHPC hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1].
Purity ≥98.0%
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