EGFR-IN-11
EGFR-IN-11 is a fourth-generation EGFR-tyrosine kinase inhibitor (EGFR-TKI) with an IC50 of 18 nM against the triple mutant EGFRL858R/T790M/C797S. It significantly inhibits EGFR phosphorylation, induces apoptosis and arrests cell cycle at G0/G1.
| Supplier | BOC Sciences |
|---|---|
| Product # | 2463200-44-2 |
| Pricing | Inquire |
| Cas | 2463200-44-2 |
| Molecular Weight | 573.71 |
| Molecular Formula | C29H35N9O2S |
| Canonical SMILES | CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C4C(=N3)N(C(=N4)NC5=CC=CC=C5)C6CCN(C6)S(=O)(=O)C7CC7 |