GDC-0077
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-101562-25 mg |
| CAS # | 2060571-02-8 |
| Pricing | 25 mg, USD $1260.0 |
| Synonyms | RG6114 |
| MWt | 407.37 |
| Formula | C₁₈H₁₉F₂N₅O₄ |
| Biological Activity | GDC-0077 (RG6114) is a potent, orally available, and selective PI3Kα inhibitor (IC50=0.038 nM). GDC-0077 (RG6114) exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. GDC-0077 (RG6114) is more selective for mutant versus wild-type PI3Kα[1]. |
| Purity | 98.94% |