PF-06372865
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-120874-10 mM * 1 mL |
| CAS # | 1614245-70-3 |
| Pricing | 10 mM * 1 mL, USD $165.0 |
| Biological Activity | PF-06372865 is an orally active, α2/α3/α5 subtype-selective GABAA positive allosteric modulator (PAM). PF-06372865 is a high affinity ligand at GABAA receptors containing α1/α2/α3/α5 subunits (Kis of 2.9 nM, 21 nM, 134 nM for α2, α1 PAM, α2 PAM, respectively), with low affinity for α4/α6 subunits. PF-06372865 can across the blood-brain barrier (BBB). PF-06372865 has anxiolytic activity and has the potential for epilepsy[1]. |
| Purity | 98.11% |
| MWt | 440.49 |
| Formula | C₂₂H₂₁FN₄O₃S |