(S,R,S)-AHPC-Me dihydrochloride
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-42424A-1 g |
| Pricing | 1 g, USD $1000.0 |
| Synonyms | VHL ligand 2 dihydrochloride; E3 ligase Ligand 1 dihydrochloride |
| MWt | 517.51 |
| Formula | C₂₃H₃₄Cl₂N₄O₃S |
| Biological Activity | (S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me dihydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM[2]. |
| Purity | 98.39% |