TL13-112
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-123919 |
| CAS # | 2229037-19-6 |
| Pricing | inquire |
| Biological Activity | TL13-112 is a potent and selective ALK-PROTAC degrader and inhibits ALK activity with an IC50 value of 0.14 nM. TL13-112 also prompts the degradation of additional kinases including Aurora A, FER, PTK2 and RPS6KA1 with IC50 values of 8550 nM, 42.4 nM, 25.4 nM, and 677 nM, respectively. TL13-112 is comprised of the conjugation of Ceritinib (HY-15656) and the cereblon ligand of Pomalidomide (HY-10984)[1]. |
| MWt | 1002.57 |
| Formula | C₄₉H₆₀ClN₉O₁₀S |