PNU-101017
PNU-101017, also known as U-101017, is a gamma-aminobutyric acid (GABA) receptor agonist potentially for the treatment of anxiety. PNU-101017 has a high affinity for the GABAA receptor subtypes containing the alpha 1 and alpha 3 or alpha 5 subunits. PNU-101017 was weakly active in anti-conflict anxiolytic tests, but attenuated the plasma corticosteroid response to mild stress in rats. PNU-101017 did not potentiate the CNS-depressant effects of ethanol, and produced no evidence of physical dependence when administered repeatedly.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD372 |
| CAS # | 170568-47-5 |
| Pricing | Customizable size, Inquiry |
| Synonym | PNU-101017; PNU101017; PNU 101017; U-101017; U 101017; U101017 |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C23H27ClN4O3 |
| Exact Mass | 442.1772 |
| Molecular Weight | 442.944 |
| Elemental Analysis | C, 62.37; H, 6.14; Cl, 8.00; N, 12.65; O, 10.84 |
| IUPAC/Chemical Name | tert-butyl 7-chloro-5-((3R,5S)-3,5-dimethylpiperazine-1-carbonyl)imidazo[1,5-a]quinoline-3-carboxylate |
| InChi Key | JOJRKTAQXYPHBT-OKILXGFUSA-N |
| InChi Code | InChI=1S/C23H27ClN4O3/c1-13-10-27(11-14(2)26-13)21(29)17-9-19-20(22(30)31-23(3,4)5)25-12-28(19)18-7-6-15(24)8-16(17)18/h6-9,12-14,26H,10-11H2,1-5H3/t13-,14+ |
| SMILES Code | O=C(C1=C2N(C=N1)C3=C(C=C(Cl)C=C3)C(C(N4C[C@@H](C)N[C@@H](C)C4)=O)=C2)OC(C)(C)C |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |