BMS-599626 Hydrochloride
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-12010-5 mg |
| CAS # | 873837-23-1 |
| Pricing | 5 mg, USD $108.0 |
| Synonyms | AC480 Hydrochloride |
| MWt | 567.01 |
| Formula | C₂₇H₂₈ClFN₈O₃ |
| Biological Activity | BMS-599626 Hydrochloride (AC480 Hydrochloride) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. BMS-599626 Hydrochloride displays ~8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 Hydrochloride inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy[1][2]. |
| Purity | 99.87% |