Bcl-xL Antibody
Bcl-xL is a 30 kDa anti-apoptotic protein belonging to the Bcl-2 family. Bcl-xL prevents apoptosis throμgh two different mechanisms: by heterodimerization with an apoptotic protein to inhibit its apoptotic effect, and by its direct pore-forming effect on the outer-membrane of mitochondria to help maintain a normal membrane state under stress conditions. Bcl-xL can be cleaved by caspases upon apoptotic activation, which converts Bcl-xL from an antiapoptotic protein to a proapoptotic cleavage product. The cleavage product of Bcl-xL forms cytochrome c-releasing pores in the mitochondrial membrane to facilitate the apoptosis signaling pathway.
| Supplier | Creative Biogene |
|---|---|
| Product # | PBCA1031 |
| Pricing | Inquiry |
| Isotype | Rabbit IgG |
| Research Area | Antibody |
| Antibody Target | Bcl-xl |
| Antibody Type | Polyclonal |
| Application | WB, IP |
| Formulation | 0.5 mg/ml of antibody in PBS, pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal |
| Appearance | Liquid |
| Host | Rabbit |
| Species Reactivity | Human, Mouse, Rat |
| Usage Statement | Our products are intended for research use only and are not to be used for other purposes, including but are not limited to in vitro diagnostic uses, ex vivo or in vivo therapeutic uses. |