ProNGF, human recombinant
The precursor form of the nerve growth factor (proNGF) like its mature form is characterized by the cystine knot motif consisting of three cystine bridges, whereas proneurotrophins and mature neurotrophins elicit opposite biological effects. ProNGF functions preferentially via the complex of pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin inducing neuronal apoptosis and contributing to age- and disease-related neurodegeneration.
| Supplier | CD BioSciences |
|---|---|
| Product # | APE-045 |
| Pricing | , Inquire |
| Product Category | Proteins/Enzymes |
| Gene ID | 4803 |
| Alternate Name | Beta-nerve growth factor (Beta-NGF) |
| Molecular Weight | 25 kDA |
| Appearance | Lyophilized protein |
| Storage Conditions | -20°C |
| Gene Symbol | NGF |
| Source | E. coli |
| Physical Form Description | Lyophilized from a 0.2 μm filtered solution of 20 mM PB and 250 mM NaCl, pH 7.2. |
| Purity by SDS-PAGE | ≥95% |
| Amino Acid Sequence | Recombinant human ProNGF produced in E. coli is a non-glycosylated, non-covalently linked homodimer with each polypeptide chain containing 222 amino acids with an extra N-terminal Met and having a molecular mass of 25 kDa. The sequence of the first five N |