Fz7-21 TFA
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-P1454A-50 mg |
| Pricing | 50 mg, USD $1650.0 |
| Synonyms | Ac-LPSDDLEFWCHVMY-NH2 TFA |
| MWt | 1910.07 |
| Formula | C₈₅H₁₁₅N₁₈F₃O₂₅S₂ |
| Biological Activity | Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA , a peptide antagonist of Frizzled 7 (FZD 7) receptors, selectively binds to FZD7 CRD subclass. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM)[1]. |
| Purity | 99.87% |