MG-277

Supplier MedChemExpress
Product # HY-130122-10 mg
CAS # 2411085-89-5
Pricing 10 mg, USD $3000.0
Biological Activity MG-277, a molecular glue degrader, effectively induces degradation of a translation termination factor, GSPT1, with a DC50 of 1.3 nM. MG-277 potently inhibits tumor cell growth in a p53-independent manner, with IC50s of 3.5 nM for RS4;11 cells and 3.4 nM for p53 mutant RS4;11/IRMI-2 cells, respectively. Anticancer activity[1].
Purity 98.94%
MWt 774.71
Formula C₄₁H₄₂Cl₂FN₅O₅
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