Prexasertib dihydrochloride
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-18174A-25 mg |
| CAS # | 1234015-54-3 |
| Pricing | 25 mg, USD $350.0 |
| Synonyms | LY2606368 dihydrochloride |
| MWt | 438.31 |
| Formula | C₁₈H₂₁Cl₂N₇O₂ |
| Biological Activity | Prexasertib dihydrochloride (LY2606368 dihydrochloride) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. Prexasertib dihydrochloride inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). Prexasertib dihydrochloride causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib dihydrochloride shows potent anti-tumor activity[1][2]. |
| Purity | 99.41% |