AKT1 / 2 / 3 (pY315 / 316 / 312) Antibody

AKT1/2/3 (pY315/316/312) Antibody is a Rabbit Polyclonal antibody against AKT1/2/3 (pY315/316/312). The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
Supplier Abbexa Ltd.
Product # abx000325-50UL
Pricing 50 µl USD $377.0
Clonality Polyclonal
Conjugation Unconjugated
Host Rabbit
Tested Applications WB, IHC, IF/ICC
UniProt Primary AC P31749, P31751, Q9Y243
Dry Ice No
Availability Shipped within 5-10 working days.
Note This product is for research use only.
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