GNE-616
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-126291 |
| CAS # | 2349371-81-7 |
| Pricing | inquire |
| Biological Activity | GNE-616 is a highly potent, metabolically stable, orally bioavailable, and subtype selective Nav1.7 inhibitor (Ki of 0.79 nM and Kd of 0.38 nM for hNav1.7) for the treatment of chronic pain. GNE-616 shows >1000 nM Kd and >2500-fold selectivity over hNav1.1, hNav1.3, hNav1.4, and hNav1.5. Selectivity over hNav1.2 and hNav1.6 is more modest at 31- and 73-fold, respectively[1]. |
| MWt | 537.53 |
| Formula | C₂₄H₂₃F₄N₅O₃S |