Dolutegravir sodium
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-13238A-10 mM * 1 mL |
| CAS # | 1051375-19-9 |
| Pricing | 10 mM * 1 mL, USD $151.0 |
| Synonyms | S/GSK1349572 sodium |
| MWt | 441.36 |
| Formula | C₂₀H₁₈F₂N₃NaO₅ |
| Biological Activity | Dolutegravir sodium (S/GSK1349572 sodium) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir sodium (S/GSK1349572 sodium) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir sodium (S/GSK1349572 sodium) retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM)[1][2]. |
| Purity | 99.96% |