YKL-5-124 TFA
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-101257B-10 mg |
| Pricing | 10 mg, USD $435.0 |
| Biological Activity | YKL-5-124 TFA is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively. YKL-5-124 TFA is >100-fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL-5-124 TFA induces a strong cell-cycle arrest, inhibits E2F-driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status[1]. |
| Purity | 98.59% |
| MWt | 629.63 |
| Formula | C₃₀H₃₄F₃N₇O₅ |