anti-ITGA4 immunotoxin 15A8 (IgG)-Gel
This immunotoxin was achieved by conjugating/fusing the Anti-ITGA4 monoclonal antibody to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to breast cancer cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then gelonin inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treatment of breast cancer.
| Supplier | Creative Biolabs |
|---|---|
| Product # | AGTO-L029G |
| Pricing | Inquiry |
| Applications | This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy. |
| Host | Mouse |
| Target | ITGA4 |
| Species Reactivity | Human |