Anti-ERBB2 immunotoxin 4D5 (scFv)-Gel
This immunotoxin was achieved by conjugating/fusing the Anti-ERBB2 scFv to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating SK-OV-3 tumor xenografts.
| Supplier | Creative Biolabs |
|---|---|
| Product # | AGTO-G022G |
| Pricing | Inquiry |
| Applications | This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy. |
| Host | Mouse |
| Target | ERBB2 |
| Species Reactivity | Human |