C-178
C-178 is a highly potent and selective small-molecule antagonist of the stimulator of interferon genes (STING) protein. It binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. C-178 also blocks palmitoylation (PMA)-induced clustering of STING. It inhibits the CMA-induced phosphorylation of TBK1, which is downstream protein kinase of STING. C-178 prevents the increases in Ifnb1 expression in bone marrow-derived macrophages (BMDMs).
| Supplier | BOC Sciences |
|---|---|
| Product # | 329198-87-0 |
| Pricing | Inquire |
| Cas | 329198-87-0 |
| Molecular Weight | 322.27 |
| Molecular Formula | C17H10N2O5 |
| Canonical SMILES | O=C(NC1=CC=C(C(C=CC=C2)=C2O3)C3=C1)C4=CC=C([N+]([O-])=O)O4 |