TC-I 15
TC-I 15 is a potent α2β1 integrin inhibitor (IC50 = 12 and 715 nM for the inhibition of human platelet adhesion to type I collagen and for platelets under static conditions and under flow, respectively), displaying selectivity for α2β1 over αvβ3, α5β1, α6β1 and αIIbβ3 at concentrations exceeding 1000 nM. TC-I 15 was shown to reduce collagen IV production in mesangial cells.
| Supplier | BOC Sciences |
|---|---|
| Product # | 916734-43-5 |
| Pricing | Inquire |
| Cas | 916734-43-5 |
| Molecular Weight | 520.62 |
| Molecular Formula | C23H28N4O6S2 |
| Canonical SMILES | CC1(C(N(CS1)S(=O)(=O)C2=CC=CC=C2)C(=O)NC(CNC(=O)NCC3=CC=CC=C3)C(=O)O)C |