Anti-CD22 immunotoxin RFB4 (IgG)-RTA
This immunotoxin was achieved by conjugating/fusing the Anti-CD22 monoclonal antibody to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of B cell lymphoma.
Supplier | Creative Biolabs |
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Product # | AGTO-G077R |
Pricing | Inquiry |
Applications | This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy. |
Host | Mouse |
Target | CD22 |
Species Reactivity | Human |