MK-2206 2HCl

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MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2.

Supplier	Selleck Chemicals
Product #	S1078
Sku #	S1078-10mM/1mL
Pricing	10mM/1mL, $220.00

Citations for this product:

Targeting the dependence on PIK3C3-mTORC1 signaling in dormancy-prone breast cancer cells blunts metastasis initiation

Islam E. Elkholi, et al., bioRxiv - Cancer Biology 2023

Quote: ... AKT-inhibitor MK-2206 2HCl (Selleck Chemicals #S1078), and VPS34-IN1 (Cayman Chemical #17392 ...
A Two-Step Activation Mechanism Enables Mast Cells to Differentiate their Response between Extracellular and Invasive Enterobacterial Infection

Christopher von Beek, et al., bioRxiv - Immunology 2023

Quote: ... MK-2206 (Selleck chemicals, #S1078), TAK-242 (Sigma-Aldrich ...
Glucagon-Like Peptide-1 Receptor Activation Stimulates PKA-Mediated Phosphorylation of Raptor and this Contributes to the Weight Loss Effect of Liraglutide

Thao D. V. Le, et al., bioRxiv - Physiology 2023

Quote: ... or the Akt inhibitor MK-2207 (Cat#S1078, Selleck Chemicals LLC) at concentrations stated in the figure legends.

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