BAY 61-3606 dihydrochloride
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-14985-50 mg |
| CAS # | 648903-57-5 |
| Pricing | 50 mg, USD $1152.0 |
| Biological Activity | BAY 61-3606 dihydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM an IC50 of 10 nM[1]. BAY 61-3606 dihydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell[2]. BAY 61-3606 dihydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates[3]. Bay 61-3606 dihydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells[4]. |
| Purity | 98.76% |
| MWt | 463.32 |
| Formula | C₂₀H₂₀Cl₂N₆O₃ |