Phospho-p90RSK (Ser380) (D5D8) Rabbit Antibody (PE Conjugate)

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Supplier CD BioSciences
Product # AMA-0028
Pricing 100 μL, Inquire
Product Category Antibodies
Application F
Product Usage Information Dilution Flow Cytometry (1:50)
Reactivity Human, Monkey, Mouse, Rat
Host Rabbit
Gene ID 6197
UniProt ID
Source/Isotype Rabbit IgG
Storage Store at -20°C.
Purification Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser377 of human p90RSK3 protein.
Background The 90 kDa ribosomal S6 kinases (RSK1-4) are a family of widely expressed Ser/Thr kinases characterized by two nonidentical, functional kinase domains and a carboxy-terminal docking site for extracellular signal-regulated kinases (ERKs). Several sites both within and outside of the RSK kinase domain, including Ser380, Thr359, Ser363, and Thr573, are important for kinase activation. RSK1-3 are activated via coordinated phosphorylation by MAPKs, autophosphorylation, and phosphoinositide-3-OH kinase (PI3K) in response to many growth factors, polypeptide hormones, and neurotransmitters.
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