Losartan Carboxylic Acid
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-12765-10 mg |
| CAS # | 124750-92-1 |
| Pricing | 10 mg, USD $135.0 |
| Synonyms | E-3174; EXP-3174 |
| MWt | 436.89 |
| Formula | C₂₂H₂₁ClN₆O₂ |
| Biological Activity | Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[1][2][3][4]. |
| Purity | 98.0% |