Vexibinol
Vexibinol is a flavonoid that has been found in S. flavescens and has diverse biological activities. It is active against 21 strains of methicillin-resistant S. aureus (MRSA; MICs = 3.13-6.25 µg/ml) and inhibits the activities of α-glucosidase and β-amylase (Kis = 5.6 and 30.6 µM, respectively). Vexibinol is cytotoxic to HL-60 and HepG2 cancer cells (IC50s = 12.5 and 13.3 µM, respectively) and induces apoptosis in HL-60 cells when used at concentrations of 10 or 25 µM. It reduces LPS-induced production of prostaglandin E2 (PGE2) in RAW 264.7 cells when used at concentrations ranging from 1 to 50 µM. Vexibinol (250 mg/kg) inhibits carrageenan-induced paw edema in rats.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1228 |
| CAS # | 97938-30-2 |
| Pricing | Customizable size, Inquiry |
| Synonym | Vexibinol; (-)-Vexibinol; Kushenol F; Kushnol F; Norkurarinone; Sophoraflavanone G; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C25H28O6 |
| Exact Mass | 424.1886 |
| Molecular Weight | 424.493 |
| Elemental Analysis | C, 70.74; H, 6.65; O, 22.61 |
| IUPAC/Chemical Name | 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(2,4-dihydroxyphenyl)-8-(5-methyl-2-(1-methylethenyl)-4-hexenyl)-, (S-(R*,S*))- |
| InChi Key | XRYVAQQLDYTHCL-CMJOXMDJSA-N |
| InChi Code | InChI=1S/C25H28O6/c1-13(2)5-6-15(14(3)4)9-18-20(28)11-21(29)24-22(30)12-23(31-25(18)24)17-8-7-16(26)10-19(17)27/h5,7-8,10-11,15,23,26-29H,3,6,9,12H2,1-2,4H3/t15-,23+/m1/s1 |
| SMILES Code | O=C1C[C@@H](C2=CC=C(O)C=C2O)OC3=C(C[C@H](C(C)=C)C/C=C(C)\C)C(O)=CC(O)=C13 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.03.00 |
| Availability | 2 Weeks |