LJI308
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-19713-10 mM * 1 mL |
| CAS # | 1627709-94-7 |
| Pricing | 10 mM * 1 mL, USD $198.0 |
| Biological Activity | LJI308 is a potent pan-ribosomal S6 kinase (RSK) inhibitor, with IC50s of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively. LJI308 inhibits the phosphorylation of RSK (T359/S363) and YB-1 (S102) after irradiation, treatment with EGF, and in cells expressing a KRAS mutation[1][2]. |
| Purity | 99.82% |
| MWt | 368.38 |
| Formula | C₂₁H₁₈F₂N₂O₂ |