1-O-Acetylbritannilactone

1-O-Acetylbritannilactone significantly reduced melanin production in a dose-dependent manner with IC50 value of 13.3 uM. inhibited melanogenesis by activating extracellular signal-regulated kinase (ERK) and Akt signaling and also inhibiting cAMP related binding protein, which regulates its downstream pathway, including tyrosinase, tyrosinase related protein-1 and TRP-2. ABL (5, 10, 20 micrommol/l) had several concentration-dependent effects, including inhibition of lipopolysaccharide (LPS)-induced PGE(2) production and COX-2 expression, and blockade of NF-kappaB activation and translocation. 1-O-Acetylbritannilactone is a potent inhibitor of LPS-stimulated VSMC inflammatory responses through blockade of NF-kappaB activity and inhibition of inflammatory gene COX-2 expression.

• Supplier: BOC Sciences
• Product #: NP5934
• Cas: 33627-41-7
• Molecular Weight: 308.37
• Molecular Formula: C17H24O5
• Canonical SMILES: CC1=C(C(C2C(C1)OC(=O)C2=C)O)C(C)CCCOC(=O)C