IC-87114
IC-87114 is a potent and ATP-competitive PI3K p110δ isoform-selective inhibitor (IC50 = 60 nM). It Inhibits p110α, p110β and p110γ only at much higher concentrations. It does not inhibit other PIK-related kinases such as ATM, ATR, DNA-PK, and mTOR even at concentrations up to 100 µM.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1540 |
| CAS # | 371242-69-2 |
| Pricing | Customizable size, Inquiry |
| Synonym | IC87114; IC-87114; IC 87114. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C22H19N7O |
| Exact Mass | 397.1651 |
| Molecular Weight | 397.442 |
| Elemental Analysis | C, 66.49; H, 4.82; N, 24.67; O, 4.03 |
| IUPAC/Chemical Name | 2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one |
| InChi Key | GNWHRHGTIBRNSM-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C22H19N7O/c1-13-6-3-4-9-16(13)29-17(27-15-8-5-7-14(2)18(15)22(29)30)10-28-12-26-19-20(23)24-11-25-21(19)28/h3-9,11-12H,10H2,1-2H3,(H2,23,24,25) |
| SMILES Code | O=C1N(C2=CC=CC=C2C)C(CN3C=NC4=C(N)N=CN=C34)=NC5=C1C(C)=CC=C5 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |