Anti-AFP immunotoxin 80G (IgG)-Gel
This immunotoxin was achieved by conjugating/fusing the Anti-AFP monoclonal antibody to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating hepatic carcinoma.
Supplier | Creative Biolabs |
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Product # | AGTO-G072G |
Pricing | Inquiry |
Applications | This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy. |
Host | Mouse |
Target | AFP |
Species Reactivity | Human |