L-733,060 HCl salt
L-733060 or L-733,060 is an orally active, non-peptide, selective antagonist for the NK1 receptor, binding with a Ki of 0.08nM. L-733,060 has antidepressant and anxiolytic effects in animal studies, and reduces both the dopamine release and neurotoxicity produced by methamphetamine and cocaine. It shows antiinflammatory and anti-hepatotoxic effects in animals, and counteracts the development of hyperalgesia following nerve injury.[15][16] It also has anticancer effects in a variety of in vitro models.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD940 |
| CAS # | 148687-76-7 (HCl) |
| Pricing | Customizable size, Inquiry |
| Synonym | L-733,060; L733,060; L 733,060; L-733060; L733060; L 733060; L-733060 HCl salt. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C20H20ClF6NO |
| Molecular Weight | 439.8264 |
| Elemental Analysis | C, 54.62; H, 4.58; Cl, 8.06; F, 25.92; N, 3.18; O, 3.64 |
| IUPAC/Chemical Name | (2S,3S)-3-{[3,5-bis(trifluoromethyl)benzyl]oxy}-2-phenylpiperidine hydrochloride |
| InChi Key | DYEUTIUITGHIEO-APTPAJQOSA-N |
| InChi Code | InChI=1S/C20H19F6NO.ClH/c21-19(22,23)15-9-13(10-16(11-15)20(24,25)26)12-28-17-7-4-8-27-18(17)14-5-2-1-3-6-14;/h1-3,5-6,9-11,17-18,27H,4,7-8,12H2;1H/t17-,18-;/m0./s1 |
| SMILES Code | FC(C1=CC(C(F)(F)F)=CC(CO[C@@H]2[C@H](C3=CC=CC=C3)NCCC2)=C1)(F)F.[H]Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |