CHIR-99021
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-10182-10 mg |
| CAS # | 252917-06-9 |
| Pricing | 10 mg, USD $108.0 |
| Synonyms | CT99021 |
| MWt | 465.34 |
| Formula | C₂₂H₁₈Cl₂N₈ |
| Biological Activity | CHIR-99021 (CT99021) is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR-99021 shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 induces autophagy[1][2][3]. |
| Purity | ≥98.0% |