EED226
EED226 is a potent, selective, and orally bioavailable a novel allosteric Polycomb repressive complex 2 (PRC2) inhibitor with an IC50 of 23.4 nM when the H3K27me0 peptide was used as substrate and an IC50 of 53.5 nM when the mononucleosome was used as the substrate. It directly binds to the H3K27me3 binding pocket of EED.
| Supplier | Selleck Chemicals |
|---|---|
| Product # | S8496 |
| Sku # | S8496-10mM/1mL |
| Pricing | 10mM/1mL, $167.00 |
Citations for this product:
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bioRxiv - Cancer Biology 2022Quote: ... The vehicle condition represents 0.1% DMSO treatment. GSK343 (Cat No. S7164) and EED226 (Cat No. S8496) were purchased from Selleck Chemicals (≥99% purity by HPLC). SETD2-IN-1 (Cat No ...