Androgen receptor antagonist 1

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Androgen receptor antagonist 1 is an orally available full androgen receptor antagonist (IC50 = 59 nM). It can be used in the synthesis of PROTAC AR degraders, which results in 24% and 47% AR protein degradation in LNCaP cells at 1 μM and 10 μM, respectively.

Supplier	BOC Sciences
Product #	1338812-36-4
Pricing	Inquire
Cas	1338812-36-4
Molecular Weight	416.90
Molecular Formula	C21H25ClN4O3
Canonical SMILES	CC1(C(C(C1OC2=CC(=C(C=C2)C#N)Cl)(C)C)NC(=O)C3=CN(N=C3)CCO)C

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