Eptapirone fumarate
Eptapirone, also known as F11440, is a potent 5HT(1A) receptor agonist with marked anxiolytic and antidepressant potential. The affinity of F 11440 for 5-HT1A binding sites (pKi, 8.33) was higher than that of buspirone (pKi, 7.50), and somewhat lower than that of flesinoxan (pKi, 8.91). In vivo, F 11440 was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone, in exerting 5-HT1A agonist activity at pre- and postsynaptic receptors in rats (measured by, for example, its ability to decrease hippocampal extracellular serotonin (5-HT) levels and to increase plasma corticosterone levels, respectively).
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD826 |
| CAS # | 179756-85-5 (fumarate) |
| Pricing | Customizable size, Inquiry |
| Synonym | Eptapirone; F11440; F-11440; F 11440. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C20H27N7O6 |
| Exact Mass | 345.1913 |
| Molecular Weight | 461.479 |
| Elemental Analysis | C, 52.05; H, 5.90; N, 21.25; O, 20.80 |
| IUPAC/Chemical Name | 4-Methyl-2-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-1,2,4-triazine-3,5-dione fumarate |
| InChi Key | IRTCWPNSLGQHOR-WLHGVMLRSA-N |
| InChi Code | InChI=1S/C16H23N7O2.C4H4O4/c1-20-14(24)13-19-23(16(20)25)8-3-2-7-21-9-11-22(12-10-21)15-17-5-4-6-18-15;5-3(6)1-2-4(7)8/h4-6,13H,2-3,7-12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+ |
| SMILES Code | O=C(N1C)N(CCCCN2CCN(C3=NC=CC=N3)CC2)N=CC1=O.O=C(O)/C=C/C(O)=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |